Synergistic activation of quorum sensing in Vibrio harveyi

Aviad Mandabi; Hadas Ganin; Michael M Meijler

doi:10.1016/j.bmcl.2015.07.028

Synergistic activation of quorum sensing in Vibrio harveyi

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3966-9. doi: 10.1016/j.bmcl.2015.07.028. Epub 2015 Jul 17.

Authors

Aviad Mandabi¹, Hadas Ganin¹, Michael M Meijler²

Affiliations

¹ Department of Chemistry and the National Institute for Biotechnology in the Negev, Be'er Sheva 84105, Israel.
² Department of Chemistry and the National Institute for Biotechnology in the Negev, Be'er Sheva 84105, Israel. Electronic address: meijler@bgu.ac.il.

PMID: 26248803
DOI: 10.1016/j.bmcl.2015.07.028

Abstract

Autoinducer-2 (AI-2) has been suggested to serve as a ubiquitous quorum sensing (QS) signal that mediates intra- and interspecies cross-talk between bacteria. To add tools for the study of its function in bacterial communication, we present a new and an improved synthetic route to AI-2 and aromatic analogues. We used this strategy to prepare naphthyl-DPD, and observed remarkably high synergistic activity at low nanomolar concentrations for this analogue in Vibrio harveyi.

Keywords: AI-2; DPD; Quorum sensing; V. harveyi.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Homoserine / analogs & derivatives*
Homoserine / chemical synthesis
Homoserine / chemistry
Homoserine / metabolism
Homoserine / pharmacology
Lactones / chemical synthesis
Lactones / chemistry
Lactones / metabolism
Lactones / pharmacology*
Molecular Structure
Quorum Sensing / drug effects*
Vibrio / drug effects*
Vibrio / metabolism

Substances

Lactones
N-octanoylhomoserine lactone
Homoserine